Improving prompt access to malaria diagnostics and treatment in rural remote areas using financial benefit for community health workers in Kilosa district, Tanzania.

This study tested the effectiveness of a financial benefit approach to motivate CHWs to improve prompt access to malaria treatment. Patients and methods: We applied a quasi-experimental study design in rural-remote areas in Kilosa district, Tanzania. Febrile children in selected intervention areas were provided access to malaria diagnostic and treatment at a minimal fee to CHWs and compared with non-intervention areas. We measured impact using difference in differences (DID) analysis. Results: At baseline, 870 children
Source: Rural Remote Health - Category: Rural Health Authors: Tags: Res Rep Trop Med Source Type: research

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Authors: Lambraño J, Curtidor H, Avendaño C, Díaz-Arévalo D, Roa L, Vanegas M, Patarroyo ME, Patarroyo MA Abstract Malaria continues being a high-impact disease regarding public health worldwide; the WHO report for malaria in 2018 estimated that ~219 million cases occurred in 2017, mostly caused by the parasite Plasmodium falciparum. The disease cost the lives of more than 400,000 people, mainly in Africa. In spite of great efforts aimed at developing better prevention (i.e., a highly effective vaccine), diagnosis, and treatment methods for malaria, no efficient solution to this disease ...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Publication date: Available online 22 February 2020Source: Microbes and InfectionAuthor(s): Luiza Carvalho Mourão, Camila Maia Pantuzzo Medeiros, Gustavo Pereira Cardoso-Oliveira, Paula Magda da Silva Roma, Jamila da Silva Sultane Aboobacar, Beatriz Carolina Medeiros Rodrigues, Ubirajara Agero, Cor Jesus Fernandes Fontes, Érika Martins BragaAbstractAutoantibodies play an important role in the destruction of non-infected red blood cells (nRBCs) during malaria. However, the relationship between this clearance and ABO blood groups is yet to be fully enlightened, especially for Plasmodium vivax infections. Here w...
Source: Microbes and Infection - Category: Infectious Diseases Source Type: research
Publication date: Available online 21 February 2020Source: Journal of EthnopharmacologyAuthor(s): I.C. Ezenyi, V. Verma, S. Singh, S.E. Okhale, B. AdzuAbstractEthnopharmacological relevanceSub – Saharan Africa has a high malaria burden and Nigeria accounts for majority of malaria cases worldwide. The aim of this study was to evaluate selected plants extracts used against malaria in Nigeria for antiplasmodial activity.Materials and methodsAn ethnomedicinal based - approach by literature survey was used to identify plants used in the study. The parts of the plant used were collected and extracted with 70% v/v ethanol; ...
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
Contributors : Maria Toro-Moreno ; Kayla SylvesterSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiens ; Plasmodium bergheiThe apicomplexan parasites Plasmodium spp. are the causative agents of malaria, a disease that poses a significant global health burden. Plasmodium spp. initiate infection of the human host by transforming and replicating within hepatocytes. Yet, despite the liver stage being a critical step during infection, most transcriptomic studies have focused on more technically accessible stages of the Plasmodium life cycle, limiting our ability to target these parasites to pr...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Plasmodium berghei Source Type: research
Abstract Parasitic diseases are a serious public health problem affecting hundreds of millions of people worldwide. African trypanosomiasis, American trypanosomiasis, leishmaniasis, malaria and toxoplasmosis are the main parasitic infections caused by protozoan parasites with over one million deaths each year. Due to old medications and drug resistance worldwide, there is an urgent need for new antiparasitic drugs. 1,3,4-Thiadiazoles have been widely studied for medical applications. The chemical, physical and pharmacokinetic properties recommend 1,3,4-thiadiazole ring as a target in drug development. Many scienti...
Source: Acta Pharmaceutica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharm Source Type: research
Condition:   Malaria,Falciparum Interventions:   Biological: PfSPZ Challenge;   Drug: Sulfadoxine-Pyrimethamine;   Drug: Piperaquine;   Drug: Artemether lumefantrine;   Drug: Primaquine Sponsors:   University of Oxford;   KEMRI-Wellcome Trust Collaborative Research Program;   Sanaria Inc.;   University Hospital Heidelberg;   Kenya Medical Research Institute Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This article will highlight the strategies used to move this critical antimalarial drug through the development pipeline. PMID: 32074317 [PubMed - in process]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Authors: Gao J, Tian Z, Yang X Abstract The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine phosphate, an old drug for treatment of malaria, is shown to have apparent efficacy and acceptable safety against COVID-19 associated pneumonia in multicenter clinical trials conducted in China. The drug is recommended to be included in the next version of the Guidelines for the Prevention, Diagnosis, and Treatment of Pneumonia Caused by COVID-19 issued by the National Health Commission of the People's Republi...
Source: BioScience Trends - Category: Biomedical Science Tags: Biosci Trends Source Type: research
[Nation] A malaria outbreak has left over 130 people seeking treatment in Bomet County in the last four days, according to local health officials.
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news
Hypophosphatemia is common in severe infections including malaria. Previous studies suggested that serum phosphate concentrations correlate with temperature, but it is unclear whether the type of infection and...
Source: Malaria Journal - Category: Infectious Diseases Authors: Tags: Research Source Type: research
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