A Novel and Cytogenetically Cryptic t(7;21)(q36.1;q22) Disrupting < b > < i > RUNX1 < /i > < /b > in Acute Myeloid Leukemia

We report here a novelRUNX1partner gene,KMT2C (MLL3), in a patient with de novo acute myeloid leukemia, having a novel and cytogenetically cryptic t(7;21)(q36.1;q22) leading to disruption ofRUNX1andKMT2C. This is the third crypticRUNX1 rearrangement in myeloid and the fourth in hematologic malignancies.Cytogenet Genome Res
Source: Cytogenetic and Genome Research - Category: Genetics & Stem Cells Source Type: research