A Triple ‐Classification Radiomics Model for the Differentiation of Primary Chordoma, Giant Cell Tumor, and Metastatic Tumor of Sacrum Based on T2‐Weighted and Contrast‐Enhanced T1‐Weighted MRI

BackgroundPreoperative differentiation between primary sacral chordoma (SC), sacral giant cell tumor (SGCT), and sacral metastatic tumor (SMT) is important for treatment decisions.PurposeTo develop and validate a triple ‐classification radiomics model for the preoperative differentiation of SC, SGCT, and SMT based on T2‐weighted fat saturation (T2w FS) and contrast‐enhanced T1‐weighted (CE T1w) MRI.Study typeRetrospective.PopulationA total of 120 pathologically confirmed sacral patients (54 SCs, 30 SGCTs, and 36 SMTs) were retrospectively analyzed and divided into a training set (n  = 83) and a validation set (n = 37).Field strength/sequenceThe 3.0T axial T2w FS and CE T1w MRI.AssessmentMorphology, intensity, and texture features were assessed based on Formfactor, Haralick, Gray ‐level co‐occurrence matrix (GLCM), Gray‐level run‐length matrix (GLRLM), histogram.Statistical testsAnalysis of variance, least absolute shrinkage and selection operator (LASSO), Pearson correlation, Random Forest (RF), area under the receiver operating characteristic curve (AUC) and accuracy analysis.ResultsThe median age of SGCT (33.5, 25.3 –45.5) was significantly lower than those of SC (58.0, 48.8–64.3) and SMT (59.0, 46.3–65.5) groups (χ2 = 37.6;P <  0.05). No significant difference was found when compared in terms of genders, tumor locations, and tumor sizes of SC, SGCT, and SMT (; P1 = 0.15, P2 = 0.29, P3 = 0.06). For the differential value...
Source: Journal of Magnetic Resonance Imaging - Category: Radiology Authors: Tags: Original Research Source Type: research