In Regard to Spratt

To the Editor: We thank Professor Spratt for his editorial, which accompanied publication of our manuscript that assessed Ki67 as a prognostic and predictive biomarker after radiation therapy in localized prostate cancer (1, 2). The editorial mentions a rather small increase in biochemical recurrence per unit increase in Ki67, which warrants clarification. We assessed Ki67 as a continuous variable using a percentage scale, as recommended in both the Transparent Reporting of a Multivariate Prediction Model for Individual Prognosis or Diagnosis statement (3) and recent literature relating to optimal use of Ki67 in breast cancer (4).
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Comment Source Type: research