A broadband method of quantifying phase synchronization for discriminating seizure EEG signals

This study focuses on developing a new EEG feature that can measure the nonlinear coupling, which thus would help improve seizure detection performance. We employ the correlation between probabilities of recurrence (CPR) to measure the PS on broadband EEG signals. CPR can capture the underlying nonlinear coupling of EEG signals and is robust to signal frequency and amplitude variance. The effectiveness of CPR-based features on identifying seizure EEG was evaluated on 26 epileptic patients with ID. Results show that the PS changes in seizures depend on the EEG discharge patterns including fast spike (SP), spike-wave (SPWA), wave (WA) and discharge with EMG activity (EMG). CPR-based PS decreased significantly in seizures with SP and EMG, (-0.1845 and -0.4278, with 95% CI [-0.1850, -0.1839] and [-0.4283, -0.4273], respectively), while it increases significantly in the SPWA seizures (+0.0746, with 95% CI [0.0744, 0.0749]). In addition, CPR-based PS shows potential for predicting SPWA and EMG seizures in an early manner. We conclude that CPR measurement is promising to improve seizure detection in ID patients and provides a promising method for modeling epilepsy-related brain functional networks.
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research