Comparison of Peripheral Blast Clearance and Day 14 Bone Marrow Biopsy in Predicting Remission Status and Survival After 7+3 Induction in Acute Myeloid Leukemia

ConclusionRapid peripheral blast clearance after 7+3 induction demonstrated a significant improvement in specificity compared to D14BM, while maintaining similar sensitivity. Neither of these methods were reliably specific tools for the decision of early re-induction, despite their prognostic value. Our findings indicate that morphological cellularity in D14BM is an independent prognostic factor for OS and RFS, regardless of blast percentage, and that ≤10% cellularity defines D14BM hypoplasia.
Source: Clinical Lymphoma Myeloma and Leukemia - Category: Cancer & Oncology Source Type: research