Pharmacological Study of Anti-inflammatory Activity of Aqueous Extracts of Mikania glomerata (Spreng.) and Mikania laevigata (Sch. Bip. ex Baker)

Publication date: Available online 9 November 2018Source: Journal of EthnopharmacologyAuthor(s): C.S.P. Della Pasqua, R.D. Iwamoto, E. Antunes, A.A. Borghi, A.C.F.H. Sawaya, E.C.T. LanducciAbstractEthnopharmacological relevanceMikania glomerata Spreng. (MG) and Mikania laevigata Sch. Bip. ex Baker (ML), popularly known as guaco, are medicinal plants similar in morphology, chemical composition and medicinal uses. Both species are often used and sold without distinction; however, it is believed that their chemical composition is different.AimThus, the aim of this study is to investigate if the aqueous extract of MG and ML present similar anti-inflammatory activity to the point of being used interchangeably.Material and MethodsDifferent doses of both extracts and coumarin were given to rats in different experimental models to assess the anti-inflammatory activity between these two species. For this, the animals were submitted to paw edema, pleurisy and degranulation of peritoneal mast cell and the extracts were also characterized by Ultra High Efficiency Liquid Chromatography coupled to Mass Spectrometry (UHPLC-MS).ResultsThe chromatographic method showed that ML presents ten times more coumarin than MG. Oral administration of MG, ML and coumarin inhibited paw edema induced by carrageenan (400 mg/kg, 55% inhibition; 400 mg/kg, 57% inhibition; 75 mg/kg, 38% inhibition; p
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research

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