Tumour immune cells could aid cancer therapies, study shows

(University of Edinburgh) A pioneering technique designed to spot differences between immune cells in tumours could speed the development of cancer treatments, research suggests.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Cancer therapy decisions are often made according to the histopathological-molecular profile of tumor tissue obtained from surgery or biopsy. It has been shown that tumor profiles change with time and treatment, and that tumor tissue is heterogeneous. Thus, other approaches that are easily accessible and less invasive than surgery or biopsy to monitor responses to treatment and predict relapses are urgently needed. In the last few years, the term “liquid biopsies” has been introduced to represent multifunctional circulating biomarkers in the peripheral blood and other physiological fluids of patients with cance...
Source: Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 16 January 2019Source: Materials Science and Engineering: CAuthor(s): Catarina A. Reis, Carolina F. Rodrigues, André F. Moreira, Telma A. Jacinto, Paula Ferreira, Ilídio J. CorreiaAbstractCancer is one of the major world public health problems and the currently available treatments are nonspecific and ineffective. This reality highlights the importance of developing novel therapeutic approaches. In this field, multifunctional nanomedicines have the potential to revolutionize the currently available treatments. These unique nanodevices can simultaneously act as therapeutic an...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Molecular PharmaceuticsDOI: 10.1021/acs.molpharmaceut.8b00836
Source: Molecular Pharmaceutics - Category: Drugs & Pharmacology Authors: Source Type: research
This study assessed gynecologists ’ and embryologists’ current practice, knowledge, and attitude concerning fertility preservation (FP) in cancer survivors. This current survey was performed on a convenience sample of 277 gynecologists and embryologists who attended large international congresses held across Iran. A 23-item self -administered questionnaire that included questions on knowledge, attitudes, and practice was used. Questions had either yes/no responses, or were answered based on a 4-point (1 to 4) Likert scored scale. Total mean score for knowledge of all FP options was 2.97 ± 0...
Source: Journal of Cancer Education - Category: Cancer & Oncology Source Type: research
Authors: De Marinis F, Barberis M, Barbieri V, Marchianò A, Gasparini S, Migliorino MR, Romano G, Spinnato F, Vitiello F, Gridelli C Abstract INTRODUCTION: In the era of personalized cancer therapy, the sampling of adequate tumor tissue for histologic diagnosis and genomic profiling is crucial, not only at the initial diagnosis but also in the event of resistant and recurrent disease when sequential biopsies may be required to evaluate somatic mutations and histologic changes. Areas covered: The identification of genetic driver alterations led to the selection of patients who are most likely to benefit from ...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Publication date: Available online 14 January 2019Source: The Journal of Steroid Biochemistry and Molecular BiologyAuthor(s): Broes Martens, Zuzanna DrebertAbstractAngiogenesis is essential in tumor development to maintain the oxygen and nutrient supply. Glucocorticoids have shown both direct and indirect angiostatic properties in various types of solid cancers. In most of the reported cases glucocorticoid-mediated actions involved suppression of multiple pro-angiogenic factors expression by cancer cells. The anti-angiogenic properties of glucocorticoids correlated with diminished tumor vasculature and reduced tumor growth...
Source: The Journal of Steroid Biochemistry and Molecular Biology - Category: Biochemistry Source Type: research
This study demonstrates the potential of developing tumor-specific treatment by specifically targeting centrosome amplification.
Source: EMBO Journal - Category: Molecular Biology Authors: Tags: Cancer, Cell Adhesion, Polarity & Cytoskeleton, Cell Cycle News [amp ] Views Source Type: research
In conclusion, our preclinical data support the hypothesis that treatment with afatinib might be a promising novel therapeutic strategy for CRC patients experiencing intrinsic and acquired cetuximab resistance.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
ConclusionsHere, we summarize current knowledge on microRNA-mediated redox regulatory mechanisms underlying chemo/radio-resistance. This knowledge may form a basis for a better clinical management of cancer patients.
Source: Cellular Oncology - Category: Cancer & Oncology Source Type: research
(University of California - San Francisco) In laboratory experiments, UC San Francisco researchers successfully beat back the growth of aggressive liver cancers using a surprising new approach. Traditionally, targeted cancer therapies aim to disable proteins borne of cancer-driving genes. Instead, the UCSF scientists prevented these proteins, including those that shield tumors from the immune system, from being built in the first place.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
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