Membrane-potential compensation reveals mitochondrial volume expansion during HSC commitment

Hematopoietic stem cells (HSCs) are normally quiescent in the bone marrow, and for their ATP needs rely predominantly on glycolysis rather than the mitochondrial tricarboxylic acid (TCA) cycle [1-6]. Therefore, mitochondrial volume was widely believed to be low in HSCs, unlike multipotent progenitor (MPP) cells, which have more respirating mitochondria with higher volumes [7-9]. Mitochondria are negatively charged, due to activity of electron transport chain (ETC) that generates a proton gradient across the mitochondrial membrane.

Source: Experimental Hematology - November 2, 2018 Category: Hematology Authors: Massimo Bonora, Kyoko Ito, Claudia Morganti, Paolo Pinton, Keisuke Ito Source Type: research