Multiple spontaneous small bowel perforations due to clozapine- Case report

CONCLUSIONThe cause was attributed to clozapine as the other etiologies were excluded. The clozapine’s reintroduction is controversial. In this case the clozapine dose was reduced successfully.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research

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Xu Zhao1, Zhi-qiang Zhou2, Ying Xiong1, Xu Chen3, Ke Xu4, Juan Li1, Ying Hu1, Xiao-long Peng1 and Wen-zhen Zhu1* 1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 2Department of Anesthesiology and Pain Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 3Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China 4Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science an...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
CONCLUSIONS: These data cross-validate previous studies that have shown that schizophrenia is associated with atypicalities in bottom-up automatic resonance processes that likely contribute to empathic and socio-emotional processing deficits, and indicate that these findings cannot be easily attributed to background contextual differences between the two groups. The results also point to a potential relationship between positive schizotypal characteristics and neurophysiological responding. Implications for simulation theories of empathy and social functioning in schizophrenia are discussed. PRACTITIONER POINTS: Empat...
Source: The British Journal of Clinical Psychology - Category: Psychiatry & Psychology Authors: Tags: Br J Clin Psychol Source Type: research
Conditions:   Acute Pain;   Chronic Pain, Widespread;   Schizophrenia Interventions:   Drug: Ketamine;   Drug: Placebo Sponsor:   Hospital de Clinicas de Porto Alegre Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
In conclusion, our data show some of the brain modifications probably responsible for the behavioral phenotype associated with TBI and suggest the CBD as a pharmacological tool to improve neurological dysfunctions caused by the trauma. Introduction The phytocannabinoid cannabidiol (CBD), the major non-psychoactive constituent of Cannabis sativa, exhibits a broad spectrum of potential therapeutic properties, including neuroprotective effects in Central Nervous System (CNS) disorders (Fernández-Ruiz et al., 2013; De Gregorio et al., 2018; Schonhofen et al., 2018). Through a multitarget mechanism, CBD shows pot...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
 Everyone has bad habits. Even your sainted Granny who seems perfect to you has some bad habit that only your grandfather knows about. Bad habits, like everything, exist on a spectrum, from biting your nails to snorting cocaine – and everything in between. In this episode, our hosts discuss bad habits that many people with mental illness seem to have – from smoking, to alcoholism, to drug use and, you guessed it, everything in between.   SUBSCRIBE &REVIEW “90% of people with schizophrenia smoke.” – Michelle Hammer   Highlights From ‘Bad Habits Mental Illness&rsq...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: A Bipolar, A Schizophrenic, and a Podcast Addiction Habits Schizophrenia Stress Source Type: blogs
Nicola Cellini1,2, Renee E. Shimizu3, Patrick M. Connolly3, Diana M. Armstrong4, Lexus T. Hernandez2, Anthony G. Polakiewicz3, Rolando Estrada3†, Mario Aguilar-Simon3, Michael P. Weisend4†, Sara C. Mednick2 and Stephen B. Simons3* 1Department of General Psychology, University of Padova, Padova, Italy 2Department of Cognitive Science, University of California, Irvine, Irvine, CA, United States 3Teledyne Scientific &Imaging, Durham, NC, United States 4Rio Grande Neurosciences, Dayton, OH, United States Transcranial electrical stimulation (tES) during sleep has been shown to successfully modula...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Conclusion It is clear that clinically, there is still much to be learnt about alexithymia and its relationship with a range of related phenomena. Firstly, is alexithymia a continuous and stable trait independent of psychological or somatic symptomology that is developed during childhood? Or is it instead a reactive state induced by trauma and distress at any age, which serves to defend against intense and upsetting emotions? This impacts on treatment options. For example, should we be focussing on early childhood interventions which target the child's emotional environment and parenting to encourage emotional exp...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Conclusion and Perspectives Since their cloning 20 years ago, the physiological importance of TREK-1 channels has continued to grow (Figure 3). Today, TREK-1 channels have been shown to be important and their presence is essential in a number of physiopathological processes. Their involvement in these different processes demonstrate the necessity to design pharmacological modulators, activators or inhibitors, of these channels to correct any TREK-1-related dysfunctions. Despites a number of studies and many molecule screenings, only few putative new drugs were identified. The activators belonging to the ML and BL series ...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion Preclinical and clinical studies have demonstrated that treatment with antipsychotics and metformin had effects on the gut microbiota and the brain. Although the mechanism of the effects of metformin on AIMD remains unclear, there are some clues in the regulation of the gut-brain axis (Figure 1). The most important connections between metformin and AIMD in the gut microbiota were the mucin-degrading bacteria A. muciniphila and several SCFA-producing bacteria, such as the phyla Firmicutes and Bacteroidetes. The gut microbiota were was influenced during AIMD, and these changes included a decrease in A. muciniphil...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Discussion of the treatment potential, or usefulness of empathy inductions for therapeutic change, is presented. • Remaining empirical questions are presented. The “Standard” Empathy Definition vs. A Non-canonical Approach to Empathy Most often, the term empathy is used to refer to the vicarious sharing of another's pain or sorrow (1). This form of empathy has been described as empathic concern (2–4) because the empathizer “shares in” the negative emotional experience of the target. However, the main argument made here is that positive-valence forms of empathy exist and should ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
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