Plasma Syndecan-1 in Hemodialysis Patients Associates with Survival and Lower Markers of Volume Status.

Plasma Syndecan-1 in Hemodialysis Patients Associates with Survival and Lower Markers of Volume Status. Am J Physiol Renal Physiol. 2018 Oct 31;: Authors: Koch J, Idzerda NMA, Dam W, Assa S, Franssen CF, van den Born J Abstract Syndecan-1, a transmembrane heparan sulfate proteoglycan, associates with renal and cardiovascular functioning. We earlier reported syndecan-1 to be involved in renal tubular regeneration. We now examined plasma values of syndecan-1 in a hemodialysis cohort and its association with volume, inflammatory and endothelial markers in addition to outcome. Predialysis syndecan-1 levels were two-fold higher in males compared to females (P=0.0003). Patients in the highest predialysis plasma syndecan-1 tertile had a significantly higher ultrafiltration rate (P=0.034) and lower plasma values of BNP (P=0.019), pro-ANP (P=0.024) and endothelin (P<0.0001) compared with the two lower predialysis syndecan-1 tertiles. No significant associations with inflammatory markers were found. Cox regression analysis showed that patients in the highest syndecan-1 tertile had significantly less CV events and better survival compared with the lowest syndecan-1 tertile (P=0.02 and P=0.005, respectively). In hemodialysis patients, higher plasma syndecan-1 levels were associated with lower concentrations of BNP, pro-ANP and endothelin, and with better patient survival. This may suggest that control of volume status in hemodialysis pati...
Source: Am J Physiol Renal P... - Category: Urology & Nephrology Authors: Tags: Am J Physiol Renal Physiol Source Type: research