In the Loop: New lungs help Tim see Mayo through new eyes

Tim Fairclough lay in a bed at Mayo Clinic's?Rochester campus, watching a happy reunion between a recent lung-transplant patient and the staff who'd cared for him before surgery. Just a day earlier, Tim had been admitted to the hospital to wait for a?lung transplant?himself. He didn't know when ? or if ? compatible lungs would [...]
Source: News from Mayo Clinic - Category: Databases & Libraries Source Type: news

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Metabolic dependence of cyclosporine A on cell proliferation of human non‑small cell lung cancer A549 cells and its implication in post‑transplant malignancy. Oncol Rep. 2019 Mar 18;: Authors: Qin X, Chen Z Abstract Cyclosporine A (CsA), a widely used immunosuppressant to prevent organ transplant rejection, is associated with an increased cancer risk following transplantation, particularly in the lung. However, the underlying mechanisms remain unclear. In the present study, using human non‑small cell lung cancer A549 cells, it was determined that CsA (0.1 or 1 µM) promoted ce...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
The objective of this report was to summarize current knowledge of CC, squamous intraepithelial lesions, and human papillomavirus (HPV) infection in non-HIV immunocompromised women to determine best practices for CC surveillance in this population and provide recommendations for screening. We evaluated those with solid organ transplant, hematopoietic stem cell transplant, and a number of autoimmune diseases. A panel of health care professionals involved in CC research and care was assembled to review and discuss existing literature on the subject and come to conclusions about screening based on available evidence and expe...
Source: Journal of Lower Genital Tract Disease - Category: OBGYN Tags: HPV-Associated Disease: Diagnosis and Management Source Type: research
ConclusionsCurrent psychosocial assessment practices in LVAD programs vary widely and often yield non-standardized, non-comparable data that may lead to variations in care and limit generation of an evidence base for decision making regarding psychosocial eligibility for LVAD implantation.
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
Conditions:   Lung Transplant;   GERD Intervention:   Device: Reflux Band Sponsor:   University of Florida Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 20 March 2019Source: CytotherapyAuthor(s): Pengbo Wang, Caixin Zhang, Jun Li, Lin Luo, Shuwen Zhang, Fulu Dong, Zhiyuan Tang, Songshi NiAbstractPulmonary arterial hypertension (PAH) is characterized by pulmonary arterial endothelial hyperproliferation and dysfunction. Restoration of endothelial function is a common goal of available treatments. In the present study, human adipose-derived mesenchymal stromal cells (ASCs) were co-cultured with monocrotaline pyrrole–treated human pulmonary arterial endothelial cells (HPAECs); increased proliferation of HPAECs and expression of vascular...
Source: Cytotherapy - Category: Cytology Source Type: research
We describe the ethical framework, logistical challenges, and rationale for the current single center (NCT03101891) and planned multicenter trial.Fetal Diagn Ther
Source: Fetal Diagnosis and Therapy - Category: Perinatology & Neonatology Source Type: research
Authors: Bewersdorf JP, Stahl M, Zeidan AM Abstract INTRODUCTION: Immune system evasion is essential for tumor cell survival and is mediated by the immunosuppressive tumor microenvironment and the activation of inhibitory immune checkpoints. While immune checkpoint-based therapy yielded impressive results in several advanced solid malignancies such as melanoma and non-small cell lung cancer, its role in acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) is still evolving. Areas covered: Here we review the immunology in the tumor microenvironment in the bone marrow and discuss the current preclinical an...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
Source: Lung - Category: Respiratory Medicine Source Type: research
Authors: Ceylan B, Yilmaz M, Beköz HS, Ramadan S, Ertan Akan G, Mert A Abstract Invasive aspergillosis is a severe infection that generally involves the lungs. Primary gastrointestinal aspergillosis is the least common form of invasive aspergillosis. A patient aged 65 years developed a febrile neutropenic episode following an autologous stem cell transplant for plasmacytoid variant diffuse large B-cell gastric non-Hodgkin's lymphoma. He had abdominal pain on the second day of the febrile neutropenic episode and ileus occurred on the sixth day. His general condition deteriorated despite broad spectrum antibioti...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
I read with great interest the original article by Oishi and colleagues1 and the corresponding letter to the Editor composed by Katz and colleagues. Oishi and colleagues' work is one of the most recent publications from the Toronto lung transplant laboratories and has to be interpreted as such. Having established a protocol, which can be used to safely perfuse human donor lungs ex  vivo, the research group has consequently taken the next step and applies this platform to treat and improve organs.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Thoracic: Lung Transplant: Reply to Letter to the Editor Source Type: research
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