Effects of Phenothiazines on Aldehyde Oxidase Activity Towards Aldehydes and N-Heterocycles: an In Vitro and In Silico Study

ConclusionThe five studied phenothiazine drugs showed dual inhibitory effects on AOX activity towards aldehydes and N-heterocycles as two major classes of enzyme substrates. Most of the interactions between the phenothiazine-related drugs and AOX in the binding pocket showed a hydrophobic nature.

http://link.springer.com/10.1007/s13318-018-0514-6

Source: European Journal of Drug Metabolism and Pharmacokinetics - October 31, 2018 Category: Drugs & Pharmacology Source Type: research