Link between Tumor-Promoting Fibrous Microenvironment and an Immunosuppressive Microenvironment in Stage I Lung Adenocarcinoma

The prognosis of even early-stage non-small-cell lung cancer (NSCLC) is critical due to local recurrence and distant metastasis following surgery [1]. Some meta-analyses and randomized trials have shown that adjuvant chemotherapy improves survival in patients with NSCLC compared to surgical intervention alone; however, this remains a controversial issue [2,3]. Clarifying the process of cancer prognosis and identification of risk factors for recurrence would help establish effective therapeutic strategies for NSCLC treatment.

Source: Lung Cancer - October 27, 2018 Category: Cancer & Oncology Authors: Takashi Sakai, Keiju Aokage, Shinya Neri, Hiroshi Nakamura, Shogo Nomura, Kenta Tane, Tomohiro Miyoshi, Masato Sugano, Motohiro Kojima, Satoshi Fujii, Takeshi Kuwata, Atsushi Ochiai, Akira Iyoda, Masahiro Tsuboi, Genichiro Ishii Source Type: research