Effects of androsterone on the protective action of various antiepileptic drugs against maximal electroshock-induced seizures in mice

There are clinically important reciprocal interactions between androgens and the brain (Pack et al., 2011; Taub øll et al., 2015). Androgens can affect functions of the central nervous system (CNS) and play an important role in the pathophysiology of various neural disorders, including epilepsy (Verrotti et al., 2007, Reddy, 2013; Taubøll et al., 2015) while epilepsy and/or antiepileptic drugs can alter and rogen levels to promote the development of reproductive hormonal disorders (Herzog and Fowler, 2005; Røste et al., 2005).

Source: Psychoneuroendocrinology - October 27, 2018 Category: Psychiatry Authors: Piotr Tutka, Katarzyna Mr óz, Tomasz Mróz, Grzegorz Buszewicz, David Aebisher, Dorota Bartusik-Aebisher, Patrycjusz Kołodziejczyk, Jarogniew J. Łuszczki Source Type: research