A case report of granulomatous polyangiitis complicated by tuberculous lymphadenitis

We report a 50-year-old woman who was diagnosed as tuberculous lymphadenitis. During the treatment by anti-tuberculosis (TB) drugs, rapidly progressive renal failure and pleurisy had appeared with elevated titer of PR3-ANCA. Renal biopsy revealed crescentic glomerulonephritis. Diagnosis: Renal biopsy revealed crescentic glomerulonephritis and diagnosis of GPA was made. Interventions: Steroid therapy had been started with continuation of anti-TB drugs. Outcomes: Renal dysfunction had gradually recovered and pleurisy had disappeared with decreasing titer of PR3-ANCA. Lessons: This is the first report of GPA complicated by TB infection. When we encounter a case with rapidly progressive renal failure during the TB infection, complication of GPA should be suspected as 1 of the different diagnosis.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research