Rotational Thromboelastometry for Coagulation Management During Cardiopulmonary Bypass Using Argatroban

Heparin-induced thrombocytopenia (HIT) is an autoimmune disorder that involves the formation of antibodies to the heparin-platelet factor 4 complex, thus leading to life-threatening thrombosis.1 Cardiac surgery with cardiopulmonary bypass (CPB) for patients with HIT requires anticoagulation using heparin alternatives and is associated with high postoperative mortality rates.2 Argatroban is a direct thrombin inhibitor used for anticoagulation during CPB in patients with HIT. The authors describe coagulation management for a case of suspected HIT requiring emergency pulmonary embolectomy with CPB.

Source: Journal of Cardiothoracic and Vascular Anesthesia - October 25, 2018 Category: Anesthesiology Authors: Yuji Hirasaki, Yosuke Yamamoto, Tomokazu Nakamura, Yuki Higa, Masahiro Honda, Shigehiko Yoshida Tags: Case Report Source Type: research