TGF- β signaling pathway mediated by deubiquitinating enzymes.

TGF-β signaling pathway mediated by deubiquitinating enzymes.
Cell Mol Life Sci. 2018 Oct 22;:
Authors: Kim SY, Baek KH
Abstract
Ubiquitination is a reversible cellular process mediated by ubiquitin-conjugating enzymes, whereas deubiquitinating enzymes (DUBs) detach the covalently conjugated ubiquitin from target substrates to counter ubiquitination. DUBs play a crucial role in regulating various signal transduction pathways and biological processes including apoptosis, cell proliferation, DNA damage repair, metastasis, differentiation, etc. Since the transforming growth factor-β (TGF-β) signaling pathway participates in various cellular functions such as inflammation, metastasis and embryogenesis, aberrant regulation of TGF-β signaling induces abnormal cellular functions resulting in numerous diseases. This review focuses on DUBs regulating the TGF-β signaling pathway. We discuss the molecular mechanisms of DUBs involved in TGF-β signaling pathway, and biological and therapeutic implications for various diseases.
PMID: 30349992 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Life Sciences : CMLS - October 22, 2018 Category: Cytology Authors: Kim SY, Baek KH Tags: Cell Mol Life Sci Source Type: research