Disseminated histoplasmosis as a first clinical manifestation in a patient with small lymphocytic lymphoma: A case report

Disseminated histoplasmosis as a first clinical manifestation in a patient with small lymphocytic lymphoma: A case report
Biomedica. 2018 09 01;38(3):298-302
Authors: Silva N, Calvache N, Arrieta E, Bravo JC, Salazar C, Rosales J, Jaramillo F, Restrepo JG
Abstract
The small lymphocytic lymphoma is a mature B cell neoplasm with a broad spectrum of clinical presentations. Opportunistic infections that are not related to the treatment, even in advanced stages, have a low incidence rate. There are few case reports in the medical literature of patients who have not received immunosuppressive therapy and present with small lymphocytic lymphoma associated with disseminated histoplasmosis at diagnosis.
A female 82-year-old patient was admitted due to an intermittent dry cough, asthenia, and adynamia that had persisted for one month. Multiple studies to detect infections and immuno-rheumatic conditions were performed and an extensive cervical, thoracic and peritoneal adenopathic syndrome was diagnosed.
A flow cytometry and a cervical lymph node biopsy were performed reporting CD19+, CD20dim, CD5+, CD45+, CD23+, CD43neg, and CD10neg phenotypes with restriction in the light kappa chain compatible with a small lymphocytic lymphoma.
Epithelioid granulomas without necrosis were observed in the lymph node histopathology and special colorations showed no microorganisms. The culture from the lymph node was positive for Histoplasma capsulatum. We init...

Source: Biomedica : Revista del Instituto Nacional de Salud - October 20, 2018 Category: International Medicine & Public Health Tags: Biomedica Source Type: research