Local cancer recurrence: The realities, challenges, and opportunities for new therapies.

Local cancer recurrence: The realities, challenges, and opportunities for new therapies. CA Cancer J Clin. 2018 Oct 17;: Authors: Mahvi DA, Liu R, Grinstaff MW, Colson YL, Raut CP Abstract Locoregional recurrence negatively impacts both long-term survival and quality of life for several malignancies. For appropriate-risk patients with an isolated, resectable, local recurrence, surgery represents the only potentially curative therapy. However, oncologic outcomes remain inferior for patients with locally recurrent disease even after macroscopically complete resection. Unfortunately, these operations are often extensive, with significant perioperative morbidity and mortality. This review highlights selected malignancies (mesothelioma, sarcoma, lung cancer, breast cancer, rectal cancer, and peritoneal surface malignancies) in which surgical resection is a key treatment modality and local recurrence plays a significant role in overall oncologic outcome with regard to survival and quality of life. For each type of cancer, the current, state-of-the-art treatment strategies and their outcomes are assessed. The need for additional therapeutic options is presented given the limitations of the current standard therapies. New and emerging treatment modalities, including polymer films and nanoparticles, are highlighted as potential future solutions for both prevention and treatment of locally recurrent cancers. Finally, the authors identify addit...
Source: Clinical Genitourinary Cancer - Category: Cancer & Oncology Authors: Tags: CA Cancer J Clin Source Type: research