Gd-EOB-DTPA DCE-MRI biomarkers in a rabbit model of liver fibrosis.

Gd-EOB-DTPA DCE-MRI biomarkers in a rabbit model of liver fibrosis. Am J Transl Res. 2018;10(9):2949-2957 Authors: Ji Y, Zhang C, Huang Z, Wang X, Yue L, Gao M, Hu H, Su Q, Han Y, Liu B, Yang D, Su Z, Zhang Z Abstract The purpose of this study was to investigate the correlations between Gd-EOB-DTPA DCE-MRI biomarkers and histopathologic biomarkers of liver fibrosis progression in a rabbit model of liver fibrosis. Thirty-Six New Zealand white rabbits were randomly divided into control (n = 6) and liver fibrosis group (n = 30). Each rabbit in the liver fibrosis group received a weekly subcutaneous injection in the back comprising 50% carbon tetrachloride (CCl4) in oily solution. Control rabbits received subcutaneous injections with the same amount of normal saline solution instead. MR imaging was performed in control and fibrotic rabbits were conducted by MRI at week 0 (n = 36). The fibrotic rabbits were performed MR imaging on 6 weeks, 9 weeks, and 12 weeks after modeling of fibrosis. Before each MRI, peripheral blood was collected, and several biochemical testes are performed. The thirty-four rabbits completed this study. They were then divided into three subgroups according to fibrotic stage: no fibrosis (F0, n = 12), mild fibrosis (F1+F2, n = 14), and advanced fibrosis (F3+F4, n = 8). DCE-MRI measurements show increasing Ktrans and Ve while decreasing iACU90 with increasing fibrosis stage. The significant correlations were observed...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research