Can Neuroimaging Predict Dementia in Parkinson's Disease? Can Neuroimaging Predict Dementia in Parkinson's Disease?

Dementia affects half of Parkinson disease patients within a decade of diagnosis. Can neuroimaging detect early signs of cognitive involvement?Brain
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

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A geroprotector is a drug or supplement that either slows the underlying causes of aging or produces a greater resistance to the damage of aging. In either case health is prolonged and mortality decreased. Calorie restriction mimetics are the best example of the type, but the category is expansive enough to include well known drugs such as aspirin. As you might imagine of a class of treatments that includes aspirin, the size of effect when it comes to additional years of life is fairly small, even in those cases in which the benefits are reliable. Geroprotectors largely work through upregulation of stress responses, someth...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
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Source: Neurology Today - Category: Neurology Tags: For Your Patients Source Type: research
The objective of this study was to investigate the discriminating value of a range of CSF α‐synuclein species for dementia with Lewy bodies compared with Alzheimer's disease, PD, and cognitively normal controls.Methods: We applied our recently published enzyme ‐linked immunosorbent assays to measure the CSF levels of total α‐synuclein, oligomeric α‐synuclein, and phosphorylated α‐synuclein in dementia with Lewy bodies (n = 42), Alzheimer's disease (n = 39), PD (n = 46), and controls (n = 78). General linear models corrected for age an...
Source: Movement Disorders - Category: Neurology Authors: Tags: Research Article Source Type: research
Today, I'll point out an analysis from the SENS Research Foundation that covers the approach to selective destruction of senescent cells taken by one of the newly formed biotech startups in the space, Senolytic Therapeutics. This field is hot because it is now well proven that senescent cells are the enemy. They are one of the root causes of aging, accumulating with age to degrade tissue function via the secretion of inflammatory signal molecules. Senescent cells actively maintain an aged, inflamed state of metabolism, resulting in the development of age-related disease and increased mortality. Senescent cells do se...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
Scientists studying the tissue bequeathed to the Sydney Brain Bank hope it will lead them to an eventual cure for neurodegenerative diseasesIt ’s a rainy Wednesday morning and Dr Andrew Affleck is driving more carefully than usual on his way to the Neuroscience Research Australia building in Randwick.It ’s not just the slick, crowded roads putting the edge on his caution; in the boot of his car, cocooned in several layers of protective container and nestled in ice, is the brain of a human being who was alive only a few hours earlier.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Medical research Health Dementia Alzheimer's Australia news Parkinson's disease Sydney Science Source Type: news
Abstract Ongoing research suggests that mitochondrial dysfunction is a common hallmark in neurodegenerative diseases, pointing to mitochondrial uncoupling process as a critical player. We recently reported that rs9472817-C/G, an intronic variant of neuronal mitochondrial uncoupling protein-4 (UCP4/SLC25A27) gene affects the risk of late onset Alzheimer's disease (LOAD), and that the variant's effect is strongly dependent on APOE-ε4 status. Here, we extended our analysis to a cohort of 751 subjects including late-onset familial and sporadic cases of frontotemporal dementia (FTD; 213), Parkinson disease (PD;...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
ConclusionsTaken together, these findings suggest that DLB have elevated levels of insoluble pS129 ‐α‐syn, but that increased levels of aqueous soluble o‐α‐syn and detergent soluble pS129‐α‐syn are also observed in PD and AD, suggesting different changes to α‐syn across the spectrum of neurodegenerative proteopathies.This article is protected by copyright. All rights reserved.
Source: Neuropathology and Applied Neurobiology - Category: Neurology Authors: Tags: Original Article Source Type: research
Conclusion: Ratios of the main proteins found in PD patient brain inclusions that can be measured in the CSF appear to have value as short ‐ to mid‐term predictors of dementia. © 2018 International Parkinson and Movement Disorder Society
Source: Movement Disorders - Category: Neurology Authors: Tags: Brief Report Source Type: research
Authors: Pang S, Li J, Zhang Y, Chen J Abstract Purpose: To clarify the relationship between certain genotypes or alleles of the APOE gene and the onset risk of Parkinson's disease dementia (PDD). Methods: The PubMed, Cochrane, Embase, CBM, CNKI, and Wanfang databases were searched to identify all case-control studies and cohort studies published before October 30, 2017, that investigated the association between the APOE gene and the onset of PDD. Manual information retrieval was also performed. All studies that met the quality requirements were included in a meta-analysis performed using RevMan 5.3 software. ...
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
Publication date: Available online 8 November 2018Source: International Review of NeurobiologyAuthor(s): Pierre-Alexandre Bourgouin, Shady Rahayel, Malo Gaubert, Dario Arnaldi, Michele Hu, Anna Heidbreder, David Rémillard-Pelchat, Michele Terzaghi, Jean-François GagnonAbstractIdiopathic rapid eye movement sleep behavior disorder (iRBD) is a parasomnia characterized by the loss of muscle atonia and the presence of undesirable motor manifestations during rapid eye movement sleep. Research findings have shown that iRBD is a prodromal stage of synucleinopathies such as Parkinson's disease, dementia with Lewy bodi...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
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