Can Neuroimaging Predict Dementia in Parkinson's Disease? Can Neuroimaging Predict Dementia in Parkinson's Disease?

Dementia affects half of Parkinson disease patients within a decade of diagnosis. Can neuroimaging detect early signs of cognitive involvement?Brain
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news

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Parkinson ’s disease (PD) is associated with both motor and non-motor symptoms, including constipation, sensory neuropathy, depression, dementia and sleep disorder. Somatostatin (SST) is considered to be a modu...
Source: Molecular Brain - Category: Neuroscience Authors: Tags: Short report Source Type: research
Contributors : Vania Broccoli ; Angelo Iannielli ; Luca Massimino ; Simone BidoSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensDysfunctions in mitochondria dynamics and metabolism are common pathological processes associated with Parkinson ’s disease (PD). Recently, it was shown that an inherited form of PD and dementia is caused by new mutations in the OPA1 gene, which encodes for a key player of mitochondrial fusion and structure. iPSC-derived neural cells from these patients exhibited severe mitochondrial fragmentation, respirati on impairment, ATP deficits and heightened oxi...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
Molecules, Vol. 24, Pages 305: Cell Responses to Extracellular α-Synuclein Molecules doi: 10.3390/molecules24020305 Authors: Alexei A. Surguchev Fatemeh Nouri Emamzadeh and Andrei Surguchov Synucleins are small naturally unfolded proteins involved in neurodegenerative diseases and cancer. The family contains three members: α-, β-, and -synuclein. α-Synuclein is the most thoroughly investigated because of its close association with Parkinson's disease (PD), dementia with Lewy bodies and multiple system atrophy. Until recently, the synuclein's research was mainly focused on their ...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Background: With an aging population, it behooves physicians and scientists to gain an understanding of the intersections between aging and human disease. Here, the author reviews the intersections between age, aging, and essential tremor (ET), particularly as these relate to disease epidemiology.Summary: The prevalence and incidence of ET both increase with age, and the former, in an exponential fashion with advanced aging. There is evidence that age may independently drive several features of the natural history of ET (e.g., the increase in tremor severity with time, the appearance of head tremor with time). Epidemiologi...
Source: Neuroepidemiology - Category: Epidemiology Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion: This case explores an available alternative for complete DBS treatment in PD, stimulating 2 targets at different frequencies with a single electrode lead.Dement Geriatr Cogn Disord 2019;47:19 –28
Source: Dementia and Geriatric Cognitive Disorders - Category: Geriatrics Source Type: research
Conclusions: Although our data are preliminary due to the small sample size, this study shows that CS is feasible and potentially effective for cognitive and noncognitive outcomes in PDD patients. Randomized controlled trials with larger sample sizes are needed to confirm these promising results. PMID: 30631420 [PubMed]
Source: Parkinsons Disease - Category: Neurology Tags: Parkinsons Dis Source Type: research
CONCLUSION: This case explores an available alternative for complete DBS treatment in PD, stimulating 2 targets at different frequencies with a single electrode lead. PMID: 30630160 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
CONCLUSION: Since the neurodegenerative disorders and dementia has continuously been increasing, wide range of therapeutic targets have been developed at cellular and molecular level. This arise the necessity of screening of these targets in different cognitive behavioral paradigms which reflect their memory enhancing potential. The understanding of behavioral models and involvement of brain structures in cognitive functions highlighted in the present review might be helpful to advance therapeutic interventions. PMID: 30648527 [PubMed - as supplied by publisher]
Source: CNS and Neurological Disorders Drug Targets - Category: Drugs & Pharmacology Authors: Tags: CNS Neurol Disord Drug Targets Source Type: research
Publication date: 2019Source: International Review of Neurobiology, Volume 144Author(s): Pierre-Alexandre Bourgouin, Shady Rahayel, Malo Gaubert, Dario Arnaldi, Michele Hu, Anna Heidbreder, David Rémillard-Pelchat, Michele Terzaghi, Jean-François GagnonAbstractIdiopathic rapid eye movement sleep behavior disorder (iRBD) is a parasomnia characterized by the loss of muscle atonia and the presence of undesirable motor manifestations during rapid eye movement sleep. Research findings have shown that iRBD is a prodromal stage of synucleinopathies such as Parkinson's disease, dementia with Lewy bodies, and multiple...
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
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