EBV-positive Mucocutaneous Ulcer: A Case Report and Review of the First 100 Published Cases

In 2016, the World Health Organization provisionally classified Epstein-Barr virus (EBV)-positive mucocutaneous ulcer (EBVMCU) as a lymphoid neoplasm under the subcategory of mature B-cell neoplasms. EBVMCU is manifested as a well-circumscribed ulcer, typically unifocal, and of the oropharynx, gastrointestinal tract, or skin. Immunohistochemical studies of these ulcers reveal monoclonal B-immunoblasts staining positively for CD20, CD30, EBER, MUM-1, OCT-2, and PAX-5 and staining variably for BCL-6, CD15, CD45, and CD79a.
Source: Clinical Lymphoma, Myeloma and Leukemia - Category: Hematology Authors: Tags: Case Report Source Type: research