The Good News Buried in Thursday ’s Soyuz Rocket Failure

One of the most technologically beautiful things you’ll ever see is a Soyuz rocket screwing up. Soyuz rockets don’t screw up often — another beautiful thing — but one did Thursday at 2:40 PM local time, over the steppes of Kazakhstan. What unfolded was a master class in how things go right when things go wrong. The rocket was intended to carry veteran Russian cosmonaut Alexey Ovchinin and rookie NASA astronaut Tyler “Nick” Hague up to low-Earth orbit for a six month stay aboard the International Space Station (ISS), joining a crew of two astronauts and one cosmonaut already aboard. Two and a half minutes after launch, the four clusters of engines that surround the rocket’s core stage shut down and fell away as they are designed to do. The central core was then supposed to ignite and then carry the crew further. That procedure is always a jolt for the crew, and a live-streaming camera inside the Soyuz spacecraft indeed showed Ovchinin and Hague getting knocked around a bit. But the knocking continued, and then Ovchinin called down “failure of the booster,” according to a CBS transcript. It’s not clear yet what that failure was, but video taken from the ground showed the four clusters tumbling through the sky, which is normal, along with other unidentified debris, which isn’t. At that moment, small rockets attached to a slender tower at the top of the Soyuz spacecraft that houses the crew did precisely what they...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized onetime space Source Type: news

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ICU patients with haematological malignancy have an increased risk of bleeding. Recently, global haemostatic methods such as thromboelastography (TEG) have gained impact in evaluating coagulation. The aim of this study was to observe whether TEG could predict bleeding in haematological ICU patients with severe sepsis. Post-hoc single-centre analysis of patients with haematological malignancy included in the Scandinavian Starch for Severe Sepsis/Septic Shock (6S) trial. Clinical characteristics, TEG measurements and details regarding bleeding complications were retrieved from the 6S database. The association between TEG and...
Source: Blood Coagulation and Fibrinolysis - Category: Hematology Tags: ORIGINAL ARTICLES Source Type: research
Conclusion: The anatomy within the temporal bone is variable amongst CI recipients. Recorded management change and significant abnormalities occurred in both CCIP groups and across many etiologies of hearing loss patients. No specific group, based on the etiology of their hearing loss could be identified that do not require preoperative HRCT. Therefore, it is recommended that all CI patients should continue to receive preoperative HRCT imaging.
Source: Otology and Neurotology - Category: ENT & OMF Tags: COCHLEAR IMPLANTS Source Type: research
Hypothesis: The aim of this study was to present and validate the accuracy of a method to predict the required cochlear implant (CI) electrode array length for a specific angular insertion depth (AID). Background: The human cochlea exhibits remarkable interindividual morphological differences. The prediction of the required array length for a specific AID can help to improve the outcome of cochlear implant surgery. Methods: We estimated the linear insertion depth required for an angular insertion of 540 degrees using computed tomography images of 16 temporal bone specimens (eight Thiel fixed, eight formalin fixed)....
Source: Otology and Neurotology - Category: ENT & OMF Tags: COCHLEAR IMPLANTS Source Type: research
Conclusion: HFms showed atraumatic surgical insertion results with consistent mid-modiolar placement. Image fusion enhances the accuracy of the insertion trauma assessment. Routine postoperative imaging is recommended for identifying tip fold-over as well as for quality control and documentation.
Source: Otology and Neurotology - Category: ENT & OMF Tags: COCHLEAR IMPLANTS Source Type: research
Conclusion: Nasal voice due to PET symptoms was observed in 17.1% of PET patients. It was generally found in patients with severe subjective symptoms. Nasal voice can be an indication of subjective severity. However, this study failed to show objective evidence of wider Eustachian tube in such cases. Patients with a nasal voice tended to seek vigorous treatment including surgery.
Source: Otology and Neurotology - Category: ENT & OMF Tags: MIDDLE EAR AND MASTOID DISEASE Source Type: research
Objective: To determine the feasibility of using temporal bone computed tomography (CT) scans to identify malleal ligaments and the prevalence of calcification in malleal ligaments. Study Design: Retrospective case review. CT scans were blindly and retrospectively reviewed by two physicians (a radiologist and a nonradiologist). Scans differed by slice thickness, and included both conventional CT and cone beam CT (CBCT). Setting: Ambulatory tertiary referral center. Patients: One hundred fifty-one temporal bone CT scans, obtained between the years 2014 and 2017, were initially screened, which included 302 ears. P...
Source: Otology and Neurotology - Category: ENT & OMF Tags: MIDDLE EAR AND MASTOID DISEASE Source Type: research
Conclusions: The radiographic prevalence of CFD is higher than what is reported in histologic studies, and may over-estimate the true prevalence of CFD. The clinician should keep this in mind when considering this as potential cause for third-window symptoms.
Source: Otology and Neurotology - Category: ENT & OMF Tags: FACIAL NERVE Source Type: research
AbstractBilateral volume reduction in the caudate nucleus has been established as a prominent brain abnormality associated with aFOXP2 mutation in affected members of the ‘KE family’, who present with developmental orofacial and verbal dyspraxia in conjunction with pervasive language deficits. Despite the gene’s early and prominent expression in the cerebellum and the evidence for reciprocal cerebellum-basal ganglia connectivity, very little is known about cere bellar abnormalities in affected KE members. Using cerebellum-specific voxel-based morphometry (VBM) and volumetry, we provide converging evidence...
Source: The Cerebellum - Category: Neurology Source Type: research
kin The purpose of this study is to highlight the surface and size effects of the nanopores on the thermodynamics and kinetics of gelation. The effects have been probed by applying differential scanning calorimetry to poly(vinylidene fluoride) solutions in tetraethylene glycol dimethyl ether (tetraglyme) and γ-butyrolactone. Nanoconfinement has been accomplished by introducing gels into native and organically modified silica nanopores (4–30 nm). Nanoconfinement has produced two major effects. First, the heat of gelation has decreased three to four times compared to that for the bulk systems. Second,...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
AbstractBackgroundMetastatic melanoma patients can have durable responses to systemic therapy and even long-term survival. However, a large subgroup of patients does not benefit. Tumour metabolic alterations may well be involved in the efficacy of both targeted and immunotherapy. Knowledge on in vivo tumour glucose uptake and its heterogeneity in metastatic melanoma may aid in upfront patient selection for novel (concomitant) metabolically targeted therapies. The aim of this retrospective study was to provide insight into quantitative18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) p...
Source: EJNMMI Research - Category: Radiology Source Type: research
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