Early detection of lung cancer biomarkers through biosensor technology: a review

This article systematically provides a brief overview of various biosensing platforms for identification of lung cancer disease biomarkers, with a specific focus on recent advancements in electrochemical and optical biosensors, analytical performances of different biosensors, challenges and further research opportunities for routine clinical analysis.Graphical abstract
Source: Journal of Pharmaceutical and Biomedical Analysis - Category: Drugs & Pharmacology Source Type: research

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ConclusionTaken together, circRNAs have potential as biomarkers for the diagnosis, prognosis, and treatment of non-small cell lung cancer.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsThis study demonstrates an important morphologic, karyotypic and phenotypic CTCs heterogeneity in advanced lung cancer patients. The majority of Vim+ CTCs are in small size and Chr8 aneuploidy. Baseline presence of Vim+ CTCs is correlated with liver metastases and may help predict poor PFS.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
ConclusionNon-US and single systemic therapy studies are more commonly associated with strict exclusion of brain metastasis in ES-SCLC trials. The strict exclusion of brain metastases in clinical trials has remained relatively constant for the past few decades.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsOur results suggested that CL-pVAX-miR-143 might be a promising strategy for clinical treatment of non-small cell lung cancer, especially for advanced NSCLC with metastasis.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research
In 60 - year follow - up, significantly lower lung cancer rates seen for those with childhood BCG vaccination
Source: The Doctors Lounge - Oncology - Category: Cancer & Oncology Tags: Family Medicine, Infections, Internal Medicine, Oncology, Pathology, Pediatrics, Pharmacy, Pulmonology, Journal, Source Type: news
ConclusionsThe effect of therapy directed toward EGFR mutation or EML4 –ALK fusion gene might obscure the significant prognostic difference between M1b and M1c.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
Four cancer centers are joining forces on a new clinical trial designed to test medically tailored meals for patients with lung cancer to combat malnutrition.
Source: CancerNetwork - Category: Cancer & Oncology Authors: Source Type: news
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Source: Cell Cycle - Category: Cytology Authors: Source Type: research
Sophie Sabbage, pictured with her daughter Gabriella, smoked ten cigarettes a day for a decade, but after quitting for good in the 1990s, she was diagnosed with terminal lung cancer.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
antovani The CCAAT box is recognized by the trimeric transcription factor NF-Y, whose NF-YA subunit is present in two major splicing isoforms, NF-YAl (“long”) and NF-YAs (“short”). Little is known about the expression levels of NF-Y subunits in tumors, and nothing in lung cancer. By interrogating RNA-seq TCGA and GEO datasets, we found that, unlike NF-YB/NF-YC, NF-YAs is overexpressed in lung squamous cell carcinomas (LUSC). The ratio of the two isoforms changes from normal to cancer cells, with NF-YAs becoming predominant in the latter. NF-YA increased expression correlates with...
Source: Genes - Category: Genetics & Stem Cells Authors: Tags: Article Source Type: research
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