Design strategies for chemical-stimuli-responsive programmable nanotherapeutics.

Design strategies for chemical-stimuli-responsive programmable nanotherapeutics.
Drug Discov Today. 2018 Oct 04;:
Authors: Gulfam M, Sahle FF, Lowe TL
Abstract
Chemical-stimuli-responsive nanotherapeutics have gained great interest in drug delivery and diagnosis applications. These nanotherapeutics are designed to respond to specific internal stimuli including pH, ionic strength, redox, reactive oxygen species, glucose, enzymes, ATP and hypoxia for site-specific and responsive or triggered release of payloads and/or biomarker detections. This review systematically and comprehensively addresses up-to-date technological and design strategies, and challenges nanomaterials to be used for triggered release and sensing in response to chemical stimuli.
PMID: 30292916 [PubMed - as supplied by publisher]

Source: Drug Discovery Today - October 4, 2018 Category: Drugs & Pharmacology Authors: Gulfam M, Sahle FF, Lowe TL Tags: Drug Discov Today Source Type: research