Insulin-like growth factor type I selectively binds to G-quadruplex structures

ConclusionsIGF-1 is demonstrated to selectively bind with G-quadruplex structures. The use of quadruplex-interactive ligands could modulate the binding of IGF-1 to G-quadruplexes.General significanceThis study provides us with a new perspective to understand the possible physiological relationship between IGF-1 and G-quadruplexes and also conveys a strategy to regulate the interaction between G-quadruplex DNA and proteins.Graphical abstractSchematic representation of the selective binding of IGF-1 for G-quadruplex structures
Source: Biochimica et Biophysica Acta (BBA) General Subjects - Category: Biochemistry Source Type: research