Guideline ‐directed statin intensification in patients with new or worsening symptoms of peripheral artery disease

Clinical Cardiology,Volume 0, Issue ja, -Not available-.
Source: Clinical Cardiology - Category: Cardiology Authors: Source Type: research

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Introduction: Cardiovascular risk reduction guidelines recommend antiplatelets and statins for all individuals with symptomatic peripheral artery disease (PAD), and antihypertensives for those with concomitant hypertension. Antiplatelet use is associated with an increased bleeding risk. We aimed to assess potential risk factors for intracranial bleeding (ICB) and gastrointestinal bleeding (GIB) in patients with symptomatic PAD.
Source: European Journal of Vascular and Endovascular Surgery - Category: Surgery Authors: Source Type: research
Abstract Background/Aims: We evaluated the contemporary use of lipid-lowering therapy (LLT) in Korean patients with atherosclerotic cardiovascular disease (ASCVD), and identified factors associated with statin non-prescription. Methods: Using the Korean Health Insurance Review and Assessment data, we identified LLT-naïve subjects newly diagnosed with ASCVD between 2011 and 2012, and followed up until 2015. LLT-naïve status was defined as no LLT prescription for 1 year before ASCVD diagnosis. ASCVD was defined as first hospitalization or emergency room visit for coronary artery disease (CAD), acute c...
Source: The Korean Journal of Internal Medicine - Category: Internal Medicine Authors: Tags: Korean J Intern Med Source Type: research
In this study, the most common reason that patients or their doctors stopped statins was the development of advanced cancer or other major illness. In my practice, I have also cared for many patients who have stopped taking statins or who express reluctance to take statins due to side effects. The most common side effect is muscle ache (typically tenderness or soreness of the large muscle groups, such as the biceps and thighs), which affects about 20% of statin takers and reverses when the statin is discontinued. There is also a slightly increased risk of diabetes with long-term statin use and, very rarely, liver problems....
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Drugs and Supplements Health Healthy Aging Heart Health Source Type: blogs
Rationale: Atherosclerotic cardiovascular disease (ASCVD), including coronary heart disease (CHD), atherosclerotic stroke and peripheral vascular disease, has become the most deadly chronic noncommunicable disease throughout the world in recent decades, while plaque regression could reduce the occurrence of ASCVD. Traditional Chinese Medicine (TCM) has been widely used for prevention and treatment of these diseases. In the perspective of TCM, phlegm and blood stasis are considered to be leading pathogenesis for CHD. Hence, activating blood circulation and dissipating phlegm, which is of great benefit to regress plaque, h...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
CONCLUSION: Atherosclerosis may be associated with an increased risk of post-stroke dementia. Post-stroke statin use was associated with decreased risk of cognitive impairment. To confirm whether or not statins confer advantages in the post-stroke population in terms of preventing cognitive decline over and above their known effectiveness in reducing risk of further vascular events, further stroke trials including cognitive assessment and observational analyses adjusted for key confounders, focusing on key subgroups or statin use patterns are required. PMID: 31505259 [PubMed - as supplied by publisher]
Source: Ageing Research Reviews - Category: Genetics & Stem Cells Authors: Tags: Ageing Res Rev Source Type: research
Walking is often touted as a perfect exercise to improve multiple aspects of health. But what if walking causes leg pain? Many people shrug off leg pain when they walk as a normal part of aging. In some cases, though, it’s the sign of peripheral artery disease (PAD), which can put heart and brain health at risk. While PAD doesn’t usually run in families, it’s more likely to occur as people age, or among people who smoke or have high blood pressure, high cholesterol, or diabetes. What causes leg pain if you have PAD? People with PAD have fatty deposits in arteries outside the heart — most often in th...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Exercise and Fitness Healthy Aging Heart Health Hypertension and Stroke Pain Management Source Type: blogs
People with peripheral artery disease (PAD) have a much lower risk of death if they take cholesterol-lowering statins as directed by their doctor, a new study reports.
Source: WebMD Health - Category: Consumer Health News Source Type: news
WEDNESDAY, Sept. 4, 2019 -- Folks with peripheral artery disease (PAD) have a much lower risk of death if they take cholesterol-lowering statins as directed by their doctor, a new study reports. About 200 million people worldwide suffer from PAD, a...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
CONCLUSION: The medical management of patients with PAD in this secondary care cohort was suboptimal. Controlling modifiable risk factors to guideline-based targets would confer significant patient benefit. PMID: 31259387 [PubMed - as supplied by publisher]
Source: The British Journal of Surgery - Category: Surgery Authors: Tags: Br J Surg Source Type: research
Abstract BACKGROUND: Acute limb ischemia (ALI) is an important clinical event and an emerging cardiovascular clinical trial outcome. Risk factors for and outcomes after ALI have not been fully evaluated. METHODS: EUCLID randomized patients with peripheral artery disease (PAD) to ticagrelor versus clopidogrel. Enrollment criteria included an ankle-brachial index (ABI) ≤0.80 or prior lower extremity revascularization. Patients were grouped according to the primary outcome, post-randomization ALI hospitalization. Baseline factors associated with ALI were identified using Cox proportional hazards modeling. Mod...
Source: Circulation - Category: Cardiology Authors: Tags: Circulation Source Type: research
More News: Cardiology | Cholesterol | Heart | Peripheral Vascular Disease (PVD) | Statin Therapy