B Cells Are the Dominant Antigen-Presenting Cells that Activate Naive CD4+ T Cells upon Immunization with a Virus-Derived Nanoparticle Antigen

Initiation of CD4+ T  cell response depends on antigen-presenting cells. Contrary to the paradigm that dendritic cells are required for this process, Hong et al. show that antigen-specific B cells are essential and sufficient to activate naive CD4+ T cells in response to virus-like particles or influenza vaccination.

Source: Immunity - October 2, 2018 Category: Allergy & Immunology Authors: Sheng Hong, Zhimin Zhang, Hongtao Liu, Meijie Tian, Xiping Zhu, Zhuqiang Zhang, Weihong Wang, Xuyu Zhou, Fuping Zhang, Qing Ge, Bing Zhu, Hong Tang, Zhaolin Hua, Baidong Hou Tags: Article Source Type: research