Experimental validation of the FLUKA Monte Carlo code for dose and β < sup > + < /sup > -emitter predictions of radioactive ion beams.

Experimental validation of the FLUKA Monte Carlo code for dose and β<sup>+</sup>-emitter predictions of radioactive ion beams. Phys Med Biol. 2018 Sep 25;: Authors: Augusto RS, Mohammadi A, Tashima H, Yoshida E, Yamaya T, Ferrari A, Parodi K Abstract In the context of hadrontherapy, whilst ions are capable of effectively destroying radio resistant, deep seated tumors, their treatment localization must be well assessed to ensure the sparing of surrounding healthy tissue and treatment effectiveness. Thus, range verification techniques, such as online positron-emission-tomography (PET) imaging, hold great potential in clinical practice, providing information on the in vivo beam range and consequent tumor targeting. Furthermore, β&lt;sup&gt;+&lt;/sup&gt; emitting radioactive ions can be an asset in online PET imaging, depending on their half-life, compared to their stable counterparts. It is expected that using these radioactive ions the signal obtained by a PET apparatus during beam delivery will be greatly increased, and exhibit a better correlation to the Bragg Peak. To this end, FLUKA &lt;i&gt;Monte Carlo&lt;/i&gt; particle transport and interaction code was used to evaluate, in terms of annihilation events at rest and dose, the figure of merit in using β&lt;sup&gt;+&lt;/sup&gt; emitter, radioactive ion beams (RIβ&lt;sup&gt;+&lt;/sup&gt;). For this purpos...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research
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