Mast cell population in the development of diabetic nephropathy: Effects of renin angiotensin system inhibition

Publication date: November 2018Source: Biomedicine & Pharmacotherapy, Volume 107Author(s): Richarlisson Borges de Morais, Victor Pereira do Couto Muniz, Emerson Nunes Costa, Sebastião Rodrigues Ferreira Filho, Karen Renata Nakamura Hiraki, Luiz Borges Bispo-da-Silva, Ana Paula Coelho BalbiAbstractConsidering the importance of the renin-angiotensin system (RAS) in diabetic nephropathy (DN) and the link between mast cells (MC) and the RAS, this study evaluated the effects of RAS blockade on the MC cell population in the kidneys from rats with experimental diabetes. Wistar rats were divided into six groups: control non-diabetic (C); sham (S); diabetic (D); and D treated with enalapril (EN), losartan (LO), or aliskiren (AL). Ninety days after diabetes induction, glomerular filtration rate (GFR) and urinary albumin excretion (UAE) were determined. Kidneys were collected for MC counting. RAS blockers minimized changes in morphometrical parameters (EN), cortical collagen (LO, AL), GFR (AL) and UAE (EN, LO). An increased number of MC was observed in the kidneys from D animals. Only AL treatment prevented this increase. MC may be involved in some aspects of DN pathogenesis and the possible protective effects of AL on the kidneys might involve MC modulation.
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research