Bone marrow transplantation restores decidualization in infertile Hoxa11 knockout mice

The decidua is a transient uterine tissue shared by mammals with hemochorial placenta and is essential for pregnancy. Hoxa11 knockout (KO) mice are infertile having endometrial stromal cell defects resulting in lack of decidualization and implantation failure. Since bone marrow (BM)-derived cells (BMDC) were shown to differentiate into non-hematopoietic endometrial cells, we hypothesized that bone marrow transplantation from wild-type (WT) mice may rescue uterine defects in Hoxa11 KO mice.
Source: Fertility and Sterility - Category: Reproduction Medicine Authors: Tags: Oral session Source Type: research