Allergen-specific sublingual immunotherapy is dose and duration dependent in a murine allergic rhinitis model

Approximately 30% of the Japanese population has Japanese cedar (JC) pollinosis, an allergic response involving sneezing, pruritus, rhinorrhea, and nasal obstruction, all of which greatly affect the patient's quality of life.1 Treatment of JC pollinosis is similar to that for other types of pollinosis and often involves antihistamine and nasal corticosteroids. Although these treatments provide symptomatic relief, they do not modify or cure the disease. In contrast, allergen-specific immunotherapy changes the course of disease,2 and sublingual immunotherapy (SLIT) is considered a safer and more efficient treatment for allergic diseases, which can be self-administered.

Source: Journal of Allergy and Clinical Immunology - August 10, 2018 Category: Allergy & Immunology Authors: Soichi Tofukuji, Kazufumi Katayama, Yoshiyuki Nakano, Satoru Ishida, Junji Tsuchida, Minako Tajiri, Yusuke Shimo, Hidekazu Tanaka, Michitaka Shichijo Tags: Letter to the Editor Source Type: research