mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington ’s Disease

Ast et  al. present the development of a FRET-based aggregate seeding (FRASE) assay that facilitates the detection and quantification of mHTT seeding activity (HSA) in complex biosamples. They show that HSA is detectable in brains of presymptomatic Huntington’s disease (HD) mice and correlates with dise ase progression and neurotoxicity in HD transgenic flies.

Source: Molecular Cell - September 6, 2018 Category: Cytology Authors: Anne Ast, Alexander Buntru, Franziska Schindler, Regine Hasenkopf, Aline Schulz, Lydia Brusendorf, Konrad Klockmeier, Gerlinde Grelle, Benjamin McMahon, Hannah Niederlechner, Isabelle Jansen, Lisa Diez, Juliane Edel, Annett Boeddrich, Sophie A. Franklin, Tags: Article Source Type: research