Limb-girdle muscular dystrophy i

The Jain clinical outcome study (COS) is an international study of 203 adults with dysferlinopathy in 8 countries. Patients undergo six visits over three years, during which physiotherapy and medical assessments as well as muscle MRI were performed. Our aim is to analyse baseline muscle pathology by MRI in a large cohort of dysferlinopathy patients and to examine the relationship between baseline muscle MRI findings and the results of longitudinal functional outcome measures over one year. We aim to identify which muscles may predict a rapid decline over one year.

Source: Neuromuscular Disorders - September 6, 2018 Category: Neurology Authors: J. Diaz-Manera, R. Fern ández-Torron, M. James, A. Mayhew, M. Jacobs, S. Spuler, J. Day, K. Jones, D. Bharucha-Goebel, E. Salort-Campana, A. Pestronk, M. Walter, C. Paradas, T. Stojkovic, M. Mori-Yoshimura, E. Bravver, E. Pegoraro, J. Mendell, K. Bushby, Source Type: research