Alpha1 and beta3 adrenergic receptor-mediated mesolimbic homeostatic plasticity confers resilience to social stress in susceptible mice

Homeostatic plasticity in mesolimbic dopamine (DA) neurons plays an essential role in mediating resilience to social stress. Recent evidence implicates an association between stress resilience and projections from the locus coeruleus to the ventral tegmental area (LC →VTA) DA system. However, the precise circuitry and molecular mechanisms of the homeostatic plasticity in mesolimbic DA neurons mediated by the LC→VTA circuitry, and its role in conferring resilience to social defeat stress, have not been described.

Source: Biological Psychiatry - September 5, 2018 Category: Psychiatry Authors: Hongxing Zhang, Dipesh Chaudhury, Alexander R. Nectow, Allyson K. Friedman, Song Zhang, Barbara Juarez, He Liu, Madeline L. Pfau, Hossein Aleyasin, Cheng Jiang, Marshall Crumiller, Erin S. Calipari, Stacy M. Ku, Carole Morel, Nikos Tzavaras, Sarah E. Mont Tags: Archival Report Source Type: research