A New Method Based on Virtual Fluence Detectors and Software Toolbox for Handheld Spectral Optoacoustic Tomography.

A New Method Based on Virtual Fluence Detectors and Software Toolbox for Handheld Spectral Optoacoustic Tomography. Adv Exp Med Biol. 2018;1072:357-361 Authors: Jiang J, Kalyanov A, Ahnen L, Lindner S, Di Costanzo Mata A, Wolf M, Sánchez Majos S Abstract A minimal setup for optoacoustic (OA) imaging requires an ultrasound probe and a pulsed laser. Such a system is capable of imaging small blood vessels and is sensitive to variations in their oxygen saturation. However, absolute oxygenation values cannot be obtained without a proper correction for the varying light fluence resulting from the optical attenuation in the surrounding tissue. Other techniques, such as near-infrared optical tomography (NIROT) can be employed to assist OA imaging for fluence compensation. In this paper, we propose using blood vessels as virtual fluence detectors (VD), which serve as light detectors for NIROT image reconstructions. By avoiding the use of real photon detectors, a simpler system could be implemented in a hand-held device comparable in size with conventional ultrasound probes. Even for a low number of VDs it provides increased informational value which, in combination with a large number of light sources, results in precise reconstructions. We define a tomographic inverse problem based on ratios of OA signals measured at several wavelengths where optical properties of VDs, tumor and normal tissue can be reconstructed simultaneously. The use of ...
Source: Adv Data - Category: Epidemiology Authors: Tags: Adv Exp Med Biol Source Type: research