Bayesian Equivalence Testing and Meta-Analysis in Two-Arm Trials with Binary Data.

Bayesian Equivalence Testing and Meta-Analysis in Two-Arm Trials with Binary Data. Comput Math Methods Med. 2018;2018:8134132 Authors: Kpekpena C, Muthukumarana S Abstract We consider a Bayesian approach for assessing hypotheses of equivalence in two-arm trials with binary Data. We discuss the development of likelihood, the prior, and the posterior distributions of parameters of interest. We then examine the suitability of a normal approximation to the posterior distribution obtained via a Taylor series expansion. The Bayesian inference is carried out using Markov Chain Monte Carlo (MCMC) methods. We illustrate the methods using actual data arising from two-arm clinical trials on preventing mortality after myocardial infarction. PMID: 30159005 [PubMed - in process]
Source: Computational and Mathematical Methods in Medicine - Category: Statistics Tags: Comput Math Methods Med Source Type: research