Blood Biomarker May Help Identify Those at Increased Risk for RCC
Concentrations of KIM-1 in the blood may predict for renal cell carcinoma up to 5 years prior to diagnosis.
This study aimed to investigate whether CD18 affects renal carcinoma cell proliferation. MATERIALS AND METHODS: Thirty mice with renal cell carcinoma were constructed using gene-engineering mouse with CD18 deficiency, and another 30 normal C57 mice were used as control. Ki67 and micro-vessel density were detected by using immunohistochemistry (IHC) and immunofluorescence, respectively. The expression of CD3, CD4 and CD8 were detected in blood and spleen by quantitative PCR (q-PCR). Flow cytometry was used to detect the changes of Treg cells. RESULTS: The expression of Ki67 in C57 was significantly higher than that in CD18-/- mice (p
Authors: Maleckaite R, Zalimas A, Bakavicius A, Jankevicius F, Jarmalaite S, Daniunaite K Abstract Metallothioneins are low‑weight cysteine‑rich proteins responsible for metal ion homeostasis in a cell and, thus, capable of regulating cell proliferation and differentiation. Deregulation of metallothionein genes has been reported in various human tumors. However, their role in renal cell carcinoma (RCC) has been poorly investigated. In the present study, we aimed to evaluate the importance of promoter DNA methylation of selected metallothionein genes for RCC. Based on the initial analysis of kidney renal clear c...
ConclusionsThis report demonstrates that using cryo-treated tumor-bearing tissue in a patient with metastatic renal cell carcinoma stimulated an antitumor cryoimmunological response.
Publication date: May 2019Source: American Journal of Kidney Diseases, Volume 73, Issue 5Author(s):
Contributors : Masaya Baba ; Mitsuko Furuya ; Takanobu Motoshima ; Martin Lang ; Shintaro Funasaki ; Wenjuan Ma ; Hong-Wei Sun ; Hisashi Hasumi ; Ying Huang ; Ikuma Kato ; Tsuyoshi Kadomatsu ; Yorifumi Satou ; Nicole Morris ; Baktiar O Karim ; Lilia Ileva ; Joseph D Kalen ; Luh Ade Wilan Krisna ; Yukiko Hasumi ; Aiko Sugiyama ; Ryoma Kurahashi ; Koshiro Nishimoto ; Masafumi Oyama ; Yoji Nagashima ; Naoto Kuroda ; Kimi Araki ; Masatoshi Eto ; Masahiro Yao ; Tomomi Kamba ; Toshio Suda ; Yuichi Oike ; Laura S Schmidt ; W M LinehanSeries Type : Expression profiling by arrayOrganism : Mus musculusRenal Cell Carcinoma (RCC) asso...
ConclusionOur patient was surprisingly still alive after metastatic disease was diagnosed 10 years ago and she had no major complaint other than a draining mass on her neck. Our primary aim by sharing this case is to underline potential renal metastasis from papillary thyroid carcinoma. In other words, when approaching primary renal tumors, possible distant metastases of other organs nee d to be kept in mind for differential diagnosis. In addition, it should be noted that if managed appropriately, the long-term survival in patients with papillary thyroid carcinoma with multiple organ metastases could be encouraging.
To investigate the diagnostic performance and usefulness of texture analysis in differentiating angiomyolipoma (AML) without visible fat from clear cell renal cell carcinoma (ccRCC) on four-phase contrast-enhanced computed tomography (CECT).
CONCLUSIONS: Our findings provide an important and robust hypothesis for a prospective clinical trial to be performed. DISCUSSION: Given the present data, patients who have symptoms suggestive of hypogonadism must have an assessment of gonadal function and be treated. PMID: 30995130 [PubMed - as supplied by publisher]
A 69-year-old male with no documented past medical history presented to an outside institution with a 2.9 cm left lower pole renal mass that was incidentally discovered on imaging performed for abdominal and back pain. He denied any history of hematuria or flank pain. He was referred to the interventional radiology service for CT-guided percutaneous biopsy and cryoablation of the left renal mass. Three core needle biopsies were performed using a 20 gauge cutting needle with coaxial technique. Hydrodissection was used to displace the colon in preparation for cryoablation due to the lesion's anterior location.
Abstract OBJECTIVE: To compare various models of diffusion-weighted imaging including monoexponential apparent diffusion coefficient (ADC), biexponential (fast diffusion coefficient [Df], slow diffusion coefficient [Ds], and fraction of fast diffusion), stretched-exponential (distributed diffusion coefficient and anomalous exponent term [α]), and kurtosis (mean diffusivity and mean kurtosis [MK]) models in the differentiation of renal solid masses. MATERIALS AND METHODS: A total of 81 patients (56 men and 25 women; mean age, 57 years; age range, 30-69 years) with 18 benign and 63 malignant lesions were ...