Comparative utility of NRG and NRGS mice for the study of normal hematopoiesis, leukemogenesis, and therapeutic response

Immune-deficient mice have revolutionized biomedical research, including the study of both normal human hematopoiesis and leukemogenesis [1 –3]. Capable of harboring both normal and malignant human xenografts without rejection, highly immune-deficient mice are indispensable in hematological research, allowing differentiation and proliferation of these cells in vivo [4]. Xenograft mouse models consistently better predict the success of experimental chemotherapeutics in clinical trials [5], likely because of the complex and dynamic interaction between the bone marrow (BM) microenvironment and heterogeneous populations of leukemic cells [6].

Source: Experimental Hematology - August 17, 2018 Category: Hematology Authors: Aditya Barve, Lavona Casson, Maxwell Krem, Mark Wunderlich, James C. Mulloy, Levi J. Beverly Source Type: research