D-Amino Acid Oxidase Inhibition: A New Glutamate Twist for Clozapine Augmentation in Schizophrenia?

Despite clozapine, many patients with schizophrenia remain treatment resistant. Unfortunately, after many clinical trials with a diverse range of agents, there remain no evidence-based clozapine augmentation strategies. Against this background, the positive results of the randomized, double-blind, placebo-controlled trial of adjunctive sodium benzoate reported by Lin et  al. (1) in this issue of Biological Psychiatry are extremely welcome, and they complement their earlier trial showing similar benefits in patients taking other antipsychotic medications (2).
Source: Biological Psychiatry - Category: Psychiatry Authors: Tags: Commentary Source Type: research