Comparative analysis of calcineurin-inhibitor-based methotrexate and mycophenolate mofetil-containing regimens for prevention of Graft-versus-Host Disease after reduced intensity conditioning allogeneic transplantation

: The combination of calcineurin inhibitor (CNI) such as tacrolimus (TAC) or cyclosporine (CYSP) with methotrexate (MTX) or with mycophenolate mofetil (MMF) has been commonly used for Graft-versus-Host Disease (GVHD) prophylaxis after reduced intensity conditioning (RIC) allogeneic transplantation (alloHCT), but there are limited data comparing efficacy of the two regimens.

https://www.bbmt.org/article/S1083-8791(18)30489-0/fulltext?rss=yes

Source: Biology of Blood and Marrow Transplantation - August 25, 2018 Category: Hematology Authors: Saurabh Chhabra, Ying Liu, Michael T. Hemmer, Luciano Costa, Joseph A. Pidala, Daniel R. Couriel, Amin M. Alousi, Navneet S. Majhail, Robert K. Stuart, Dennis Kim, Olle Ringden, Alvaro Urbano-Ispizua, Ayman Saad, Bipin N. Savani, Brenda Cooper, David I. M Source Type: research