LB1546 New molecular pathways in skin vasculature development

During embryonic development, lymphatic vessels grow from specialized endothelial cells present in preexisting blood vessels. Molecular signals that regulate the separation or differentiation of blood to lymph vessels as well as the proliferation of lymphatics throughout the embryonic body are not well defined. Here, we present a mouse model that displays with severe edema, anemia and vascular hemorrhaging during mid-gestation (14.5-16.5 days post-coitum) at elevated penetrance ( ∼90%) resulting in embryonic lethality.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Genetic Disease, Gene Regulation and Gene Therapy Source Type: research