Serum bactericidal activity of colistin and azidothymidine combinations against mcr-1 positive colistin-resistant Escherichia coli

Gram-negative bacteria, especially Enterobacteriaceae, are the major cause of both community and hospital-acquired urinary tract infections (UTI), which is worsened by the continuous antibiotic resistance emergence and a shortage of new antibiotics under development. The number of antimicrobial agents to medicate infections caused by antibiotic-resistant Enterobacteriaceae is limited, and the polymyxins such as colistin are considered the last resort treatment [1].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Source Type: research