Serum bactericidal activity of colistin and azidothymidine combinations against mcr-1 positive colistin-resistant Escherichia coli
Gram-negative bacteria, especially Enterobacteriaceae, are the major cause of both community and hospital-acquired urinary tract infections (UTI), which is worsened by the continuous antibiotic resistance emergence and a shortage of new antibiotics under development. The number of antimicrobial agents to medicate infections caused by antibiotic-resistant Enterobacteriaceae is limited, and the polymyxins such as colistin are considered the last resort treatment [1].
Source: International Journal of Antimicrobial Agents - Category: Drugs & Pharmacology Authors: Maria Loose, Kurt G. Naber, Yanmin Hu, Anthony Coates, Florian M.E. Wagenlehner Source Type: research
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