Classical molecular dynamics and metadynamics simulations decipher the mechanism of CBP30 selectively inhibiting CBP/p300 bromodomains

Org. Biomol. Chem., 2018, Accepted Manuscript DOI: 10.1039/C8OB01526K, PaperQianqian Wang, Xiaoli An, Jiahui Xu, Yuwei Wang, Liang Liu, Lai-Han Leung, Xiaojun Yao Selective modulation of individual bromodomains (BDs) by small molecules represents an important strategy for the treatment of various cancers, considering that the BD-containing proteins share common BD structures and distinct... The content of this RSS Feed (c) The Royal Society of Chemistry

Source: RSC - Organic and Biomolecular Chemistry - August 20, 2018 Category: Molecular Biology Authors: Qianqian Wang Source Type: research