Right ventricular base/apex ratio in the assessment of pediatric pulmonary arterial hypertension: Results from the European Pediatric Pulmonary Vascular Disease Network

Clinical Cardiology, EarlyView.
Source: Clinical Cardiology - Category: Cardiology Authors: Source Type: research

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Once in a very rare while, a single, serious challenge consumes the attention of the entire world. We are living through one such period today as countries and communities come together to end the new coronavirus outbreak. This virus, provisionally known as the “2019-novel coronavirus,” has, as of 3 February 2020, spread to 24 countries, with over 17,000 people being infected to date, 99% of them in China. The limited numbers of cases elsewhere around the world – just 153 so far – show that efforts to contain the virus in China are curbing its global spread, alongside the detection and clinical care...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized health ideas Source Type: news
Abstract BACKGROUND: Echocardiographic determination of the right ventricular end-systolic remodeling index (RVES RI) has clinical value for the assessment of pulmonary hypertension (PH) in adults. We aim to determine RVES RI values in pediatric PH and to correlate RVES RI data with echocardiographic variables and NYHA functional class (FC). METHODS: Prospective echocardiography study in 49 children with PH. The 49 matched control subjects were chosen from 123 healthy children used to construct pediatric normal reference values. The associations with invasive hemodynamic variables were also investigated in a ...
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research
Background: Sjögren syndrome may be complicated by pulmonary hypertension (PH). However, there are no data available from prospective studies regarding its prevalence.Aims: We aimed to assess the prevalence of PVD including PH, borderline mPAP (20-24mmHg) and exercise PH (EPH) in patients with primary and secondary Sjögren syndrome.Methods: Consecutive patients with Sjögren syndrome underwent echocardiography at rest and during exercise. They were assigned to a low-, intermediate- or high-risk group according to their resting SPAP and their mPAP/CO slope during exercise. In high-risk patients (SPAP≥38mmHg, suspect...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Pulmonary hypertension Source Type: research
Prior studies reported that haploinsufficiency of the transcription factor ETS-1 is renoprotective in Dahl salt-sensitive rats, but the mechanism is unclear. Here, we tested whether ETS-1 is involved in hypertension-induced renal microvascular pathology and autoregulatory impairment. Hypertension was induced in salt-sensitive rats and salt-sensitive rats that are heterozygous with one wild-type or reference allele of Ets1 (SSEts1+/-) by feeding a diet containing 4% sodium chloride for one week. Increases in blood pressure did not differ.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Basic Research Source Type: research
Abstract Endothelins (EDNs) and their receptors (EDNRs) are reported to be involved in the regulation of many physiological/pathological processes, such as cardiovascular development and functions, pulmonary hypertension, neural crest cell proliferation, differentiation and migration, pigmentation, and plumage in chickens. However, the functionality, signaling, and tissue expression of avian EDN-EDNRs have not been fully characterized, thus impeding our comprehensive understanding of their roles in this model vertebrate species. Here, we reported the cDNAs of three EDN genes (EDN1, EDN2, EDN3) and examined the fun...
Source: General and Comparative Endocrinology - Category: Endocrinology Authors: Tags: Gen Comp Endocrinol Source Type: research
CONCLUSION: A long cervix in the third trimester is not associated with a prolonged first stage of labor. Induction of labor and multiparity were associated with a shorter first stage of labor while hypertension was associated with a longer duration of labor. PMID: 31312917 [PubMed - as supplied by publisher]
Source: Wiener Klinische Wochenschrift - Category: General Medicine Authors: Tags: Wien Klin Wochenschr Source Type: research
This study demonstrated that the incidence of ischemic heart disease and death were three times higher among men with low birth weight compared to men with high birth weight (5). Epidemiological investigations of adults born at the time of the Dutch famine between 1944 and 1945 revealed an association between maternal starvation and a low infant birth weight with a high incidence of hypertension and coronary heart disease in these adults (23). Furthermore, Painter et al. reported the incidence of early onset coronary heart disease among persons conceived during the Dutch famine (24). In that regard, Barker's findin...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Publication date: Available online 2 February 2019Source: Canadian Journal of CardiologyAuthor(s): Stefan Kurath-Koller, Alexander Avian, Massimiliano Cantinotti, Ante Burmas, Gernot Grangl, Sabrina Schweintzger, Andreas Gamillscheg, Martin KoestenbergerAbstractBackgroundThe clinical value of determination of right ventricular (RV) function in adults using echocardiographic determination of the subcostal tricuspid annular plane systolic excursion (S-TAPSE) has previously been reported. We aim to provide representative, normal reference values for S-TAPSE in the pediatric age group. Moreover, validation of abnormal S-TAPSE ...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
In this study, we found that TNF-α resulted in an impairment of autophagic flux in microglia. Concomitantly, an increase of M1 marker expression and reduction of M2 marker expression were observed in TNF-α challenged microglia. Upregulation of autophagy via serum deprivation or pharmacologic activators (rapamycin and resveratrol) promoted microglia polarization toward M2 phenotype, as evidenced by suppressed M1 and elevated M2 gene expression, while inhibition of autophagy with 3-MA or Atg5 siRNA consistently aggravated the M1 polarization induced by TNF-α. Moreover, Atg5 knockdown alone was suffic...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Background: Liver cirrhosis may cause left ventricular diastolic dysfunction (LVDD). It is not known if this has an impact on physical capacity.Aims: We aimed to evaluate the prevalence of LVDD and its impact on physical capacity in a prospective cohort of patients with cirrhosis of all Child-Pugh (CP) stages.Methods: Patients were enrolled between 2011 and 2016. Cardiopulmonary exercise testing-derived peak VO2, 6min walk test (6MWT), echocardiography, laboratory testing and lung function testing were performed. Patients with LVEF
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical respiratory physiology, exercise and functional imaging Source Type: research
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