Limbic response to stress linking life trauma and hypothalamus-pituitary-adrenal axis function

Lifetime trauma exposure has been shown to significantly impact physical and psychological well-being, increasing risk for stress-related disorders and negative health outcomes (Bevans et al., 2008; McEwen, 2002; Sinha, 2008). Studies have identified the neurobiological underpinnings of trauma exposure; this line of studies has largely found altered function associated with trauma in two stress-related pathways, the hypothalamic –pituitary–adrenal (HPA) axis system (Fries et al., 2005) and limbic brain regions (McEwen, 2001; Williams et al., 2006).

Source: Psychoneuroendocrinology - August 17, 2018 Category: Psychiatry Authors: Dongju Seo, Arielle G. Rabinowitz, Ryan J. Douglas, Rajita Sinha Source Type: research