Molecules, Vol. 23, Pages 2066: A Polyphenol Rich Extract from Solanum melongena L. DR2 Peel Exhibits Antioxidant Properties and Anti-Herpes Simplex Virus Type 1 Activity In Vitro
Molecules, Vol. 23, Pages 2066: A Polyphenol Rich Extract from Solanum melongena L. DR2 Peel Exhibits Antioxidant Properties and Anti-Herpes Simplex Virus Type 1 Activity In Vitro
Molecules doi: 10.3390/molecules23082066
Authors:
Antonella Di Sotto
Silvia Di Giacomo
Donatella Amatore
Marcello Locatelli
Annabella Vitalone
Chiara Toniolo
Giuseppe Leonardo Rotino
Roberto Lo Scalzo
Anna Teresa Palamara
Maria Elena Marcocci
Lucia Nencioni
DR2B and DR2C extracts, obtained by ethanolic maceration of peel from commercially and physiologically ripe aubergine berries, were studied for the antioxidative cytoprotective properties and anti-HSV-1 activity, in line with the evidence that several antioxidants can impair viral replication by maintaining reducing conditions in host cells. The antioxidative cytoprotective effects against tBOOH-induced damage were assessed in Caco2 cells, while antiviral activity was studied in Vero cells; polyphenolic fingerprints were characterized by integrated phytochemical methods. Results highlighted different compositions of the extracts, with chlorogenic acid and delphinidin-3-rutinoside as the major constituents; other peculiar phytochemicals were also identified. Both samples reduced reactive oxygen species (ROS) production and exhibited scavenging and chelating properties. DR2C partly counteracted the tBOOH-induced cytotoxicity, with a remarkable lowering of lactate metabolism under both normoxia and hypoxia; interestingly,...
Source: Molecules - Category: Chemistry Authors: Antonella Di Sotto Silvia Di Giacomo Donatella Amatore Marcello Locatelli Annabella Vitalone Chiara Toniolo Giuseppe Leonardo Rotino Roberto Lo Scalzo Anna Teresa Palamara Maria Elena Marcocci Lucia Nencioni Tags: Article Source Type: research