Metabolism of primaquine in normal human volunteers: investigation of phase I and phase II metabolites from plasma and urine using ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry

Primaquine (PQ), an 8-aminoquinoline, is the only drug approved by the United States Food and Drug Administration for radical cure and prevention of relapse in Plasmodium vivax infections. Knowledge of the metabo...

Source: Malaria Journal - August 13, 2018 Category: Infectious Diseases Authors: Bharathi Avula, Babu L. Tekwani, Narayan D. Chaurasiya, Pius Fasinu, N. P. Dhammika Nanayakkara, H. M. T. Bhandara Herath, Yan-Hong Wang, Ji-Yeong Bae, Shabana I. Khan, Mahmoud A. Elsohly, James D. McChesney, Peter A. Zimmerman, Ikhlas A. Khan and Larry A Tags: Research Source Type: research