Arctiin is a specific inhibitor of STAT3 phosphorylation in tyrosine 705 residue and potentiates bortezomib-induced apoptotic, proliferative, and angiogenetic effects in human multiple-myeloma cells

ConclusionOn the whole, our results indicate that arctiin is a potentially new inhibitor of constitutive STAT3 activation through the induction of PTPε in MM, cells and therefore has great value in treating various tumors sheltering constitutively activated STAT3.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research